After freeing Dean (Jensen Ackles) from the Mark of Cain, it's Sam's turn to get infected by a sickness that was brought forth from by the Darkness that the brothers unwittingly released.
Catch the "Supernatural" season 11 episode 1 online now to find out the Winchesters' fate after being swallowed by the mysterious dark cloud!
While enveloped in the Darkness, a woman thanked the eldest Winchester for setting her free but also admitted that she felt "peaceful" with him.
"We're bound," she then told him, showing her own Mark of Cain. "We'll always be bound. You helped me. We will always help each other."
Dean's internal struggle with the Darkness aside, the brothers eventually had to face the aftermath of the Darkness' freedom on Earth. The first challenge? A town filled with people infected by some kind of virus that makes them violent.
The ordeal made Sam (Jared Padalecki) bring up and question the family credo. Shouldn't they be saving people and not just a single person or each other?
"When did we forget how to do this?" he started asking. "Dean, if we don't change, right now, all of our crap is just going to keep repeating ourselves... Saving people means all of the people, not just that baby, not just each other."
Executive producer Jeremy Carver previously assured fans that the brothers will be united this season, fighting a mysterious enemy that even angels and demons have no inkling of. The bromance would reportedly be turned up even more, and the first episode already tested this by having Sam question everything they worked for in the past decade.
Watch "Supernatural" season 11 episode 1 online again on the CW for free here or in Hulu here to find out if Sam survived the infection or if he turned into a mindless violent version of himself instead
Sam's infection isn't the only twist in the premiere. The baby named Amara, whose father was infected by the virus, turned out to be the Mark of Cain's new home, according to International Business Times.
Will the brothers save this child or will they kill her for the sake of mankind. Find out by catching up on the "Supernatural" season 11 episode 1 online.
